Sigmaplot 11 mega9/6/2023 ![]() In series-1, rats received 50 ♜i of tritium-labeled 2-deoxyglucose (DOG) harvesting their hearts at baseline (n=5), during VF (n=5), during resuscitation (n=6), and at post-resuscitation 60 minutes (n=5) and 240 minutes (n=5). Two series of 26 and 18 rats each underwent 10 minutes of untreated VF before attempting resuscitation. ![]() We used a rat model of ventricular fibrillation (VF) and closed-chest resuscitation to examine whether the mPTP opens in vivo and whether cyclosporine A (CsA) attenuates the associated myocardial injury. Yet, most of our knowledge comes from observations in isolated mitochondria, cells, and organs. Opening of the mitochondrial permeability transition pore (mPTP) is considered central to reperfusion injury.
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